WHAT IS DIRECT EFFECTS?
What is Direct Effects?
Direct Effects™ Topical Drug Therapy is a novel approach to deliver neuro-active drugs directly into nerve tissue bypassing traditional means of absorption, distribution and excretion. This technology may result in lower drug exposure, increased delivery to target sites and decreased potential for side effects and drug interactions.
Current therapies usually require oral entry, injection, or transdermal patch to achieve a therapeutic blood level. In the case of oral administration the drug must be absorbed through the gastro-intestinal system, metabolized by the liver and/or kidneys, distributed through the vascular system and eventually find its way to the targeted tissue in the brain. Presence of the “blood-brain-barrier” prevents many drugs from effectively reaching target sites in the brain. While some may reach the brain in small amounts, others are unable to cross the barrier altogether. As Direct Effects works through direct nerve connections without involvement of blood, this is not an issue with drugs delivered in this way.
It is further believed that many reported adverse reactions caused by the administration of neuro-active drugs are due to systemic distribution of the agent to non-targeted sites throughout the body.
It is these unwanted adverse events and side effects that limit the effectiveness and tolerability of many of these drugs in consumer use.
Replacing oral and other systemic routes of administration, the Direct Effects™ Topical Drug Therapy is believed to work by penetrating peripheral nerve endings providing a direct avenue to neural tissue within the brain. It is the proliferation of nerve endings close to the surface of the skin at the back of the neck that provides the conduit for success with the Direct Effects™ Topical Drug Therapy.
The use of the Direct Effects™ Topical Drug Therapy has in observational data provided therapeutic benefit and no systemic adverse effects when using many different active drugs. This has been accomplished with a fraction of the normally required dose.